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Mathematical model for GAPDH kinetics, saturation of GAP, BPG, NADP, NADPH and Pi.

**SEEK ID:** https://demo.fairdomhub.org/assays/24

Modelling Analysis

**Projects:** SulfoSys

**Investigation: **
Central Carbon Metabolism of Sulfolobus solfataricus

**Study: **
Model gluconeogenesis

**Biological problem addressed:**
Model Analysis Type

**Organisms**: Sulfolobus solfataricus : P2 (wild-type / wild-type)

**Model:**

**Data:**

- GAPDH kinetics 3PG
- GAPDH kinetics GAP
- GAPDH kinetics NADP
- GAPDH kinetics NADPH
- GAPDH kinetics Pi
- Hidden Data file (Construction data)

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**Views:** 2993

**Created**: 1st Feb 2013 at 00:11

**Last updated**: 26th Oct 2017 at 11:57

## Related items

- People (1)
- Projects (1)
- Investigations (1)
- Studies (1)
- Strains (1)
- Data files (5+1)
- Models (1)
- Publications (1)

Silicon cell model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation

**Programme**: SysMO

**Public web page**: http://sulfosys.com/

**Organisms:** Sulfolobus solfataricus

An investigation in the CCM of S. solfataricus with a focus on the unique temperature adaptations and regulation; using a combined modelling and experimental approach.

**Snapshots: **Snapshot 1

**Studies:** Carbon loss at high T, Model gluconeogenesis, Pathway optimisation

**Assays:** Experimental assays of the temperature dependent degradation of GAP and ..., FBPA/ase, FBPAase model, GAPDH, GAPDH modeling, Gluconeogenic model, Model reconstituted system, Modelling pathway optimisation, Modelling temperature dependent degradation of GAP and DHAP, PGK, PGK and FBPAase titrations, PGK modeling, Reconstituted system reference state, TPI, TPI modeling

**Scales:**
Not specified

Mathematical model of a subset of reactions comprising the three most temperature sensitive intermediates of the gluconeogenic pathway in S. solfataricus

**Person responsible**: Jacky Snoep

**Snapshots: **No snapshots

**Investigation:** Central Carbon Metabolism of Sulfolobus solfata...

**Assays:** Experimental assays of the temperature dependent degradation of GAP and ..., FBPA/ase, FBPAase model, GAPDH, GAPDH modeling, Gluconeogenic model, Modelling temperature dependent degradation of GAP and DHAP, PGK, PGK modeling, TPI, TPI modeling

**Scales:**
Not specified

**Contributor**: Not available

**Provider Name**: Not specified

**Provider's strain ID**: Not specified

**Organism**: Sulfolobus solfataricus

**Genotypes**: wild-type

**Phenotypes**: wild-type

**Comment**: Not specified

**Investigations:** Central Carbon Metabolism of Sulfolobus solfata...

**Studies:** Model gluconeogenesis

**Assays:** GAPDH, GAPDH modeling

**Scales:**
Not specified

**Investigations:** Central Carbon Metabolism of Sulfolobus solfata...

**Studies:** Model gluconeogenesis

**Assays:** GAPDH, GAPDH modeling

**Scales:**
Not specified

**Investigations:** Central Carbon Metabolism of Sulfolobus solfata...

**Studies:** Model gluconeogenesis

**Assays:** GAPDH, GAPDH modeling

**Scales:**
Not specified

**Investigations:** Central Carbon Metabolism of Sulfolobus solfata...

**Studies:** Model gluconeogenesis

**Assays:** GAPDH, GAPDH modeling

**Scales:**
Not specified

**Investigations:** Central Carbon Metabolism of Sulfolobus solfata...

**Studies:** Model gluconeogenesis

**Assays:** GAPDH, GAPDH modeling

**Scales:**
Not specified

Mathematical model for GAPDH kinetics, saturation for GAP, BPG, NADP, NADPH, Pi.

**Creator: **Jacky Snoep

**Contributor**: Jacky Snoep

**Model type**: Ordinary differential equations (ODE)

**Model format**: Mathematica

**Environment**: Not specified

**Organism**: Sulfolobus solfataricus

**Investigations:** Central Carbon Metabolism of Sulfolobus solfata...

**Studies:** Model gluconeogenesis

**Modelling analyses:** GAPDH modeling

**Scales:**
Not specified

**Abstract** (Expand)

**Authors: **T. Kouril, D. Esser, J. Kort, H. V. Westerhoff, B. Siebers, Jacky Snoep

**Date Published**: 22nd Aug 2013

**Journal**: FEBS J

**PubMed ID**: 23865479

**Citation**: FEBS J. 2013 Sep;280(18):4666-80. doi: 10.1111/febs.12438. Epub 2013 Aug 22.

**Scales:**
Not specified