Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry
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This study examines whether the in vivo behavior of yeast glycolysis can be understood in terms of the in vitro kinetic properties of the constituent enzymes.
SEEK ID: https://demo.fairdomhub.org/studies/5
Growth control of the eukaryote cell: a systems biology investigation into yeast
Projects: SysMO DB
Projects: SysMO DB
Created: 5th Jul 2010 at 14:27
Last updated: 4th Nov 2011 at 10:06
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Institutions: University of Amsterdam, School of Computer Science, University of Manchester
Expertise: Biochemistry, Bioinformatics, Data Management
Tools: Data Management, Transcriptomics, Databases, Workflows, Web services, Taverna, Ontologies
I am a Research Fellow at the University of Manchester, working in Bioinformatics and Computer Science. I am also a guest researcher at the Vrije Universiteit.My research interests include scientific workflows, semantic discovery, and applying ontology technologies to biological data
SysMO is a European transnational funding and research initiative on "Systems Biology of Microorganisms".
The goal pursued by SysMO is to record and describe the dynamic molecular processes going on in unicellular microorganisms in a comprehensive way and to present these processes in the form of computerized mathematical models.
Systems biology will raise biomedical and biotechnological research to a new quality level and contribute markedly to progress in understanding. Pooling European research ...
Projects: BaCell-SysMO, COSMIC, SUMO, KOSMOBAC, SysMO-LAB, PSYSMO, SCaRAB, MOSES, TRANSLUCENT, STREAM, SulfoSys, SysMO DB
Web page: http://sysmo.net/
The main objectives of SysMO-DB are to: facilitate the web-based exchange of data between research groups within- and inter- consortia, and to provide an integrated platform for the dissemination of the results of the SysMO projects to the scientific community. We aim to devise a progressive and scalable solution to the data management needs of the SysMO initiative, that:
- facilitates and maximises the potential for data exchange between SysMO research groups;
- maximises the ‘shelf life’ and ...
Public web page: http://www.sysmo-db.org/
Organisms: Saccharomyces cerevisiae, Lactic Acid Bacteria
Cell growth underlies many key cellular and developmental processes, yet a limited number of studies have been carried out on cell-growth regulation. Comprehensive studies at the transcriptional, proteomic and metabolic levels under defined controlled conditions are currently lacking.
This investigation shows public data taken from the BioInvestigation Index. (http://www.ebi.ac.uk/bioinvindex/study.seam?studyId=BII-S-1) Organism: Saccharomyces Cerevisiae
Submitter: Katy Wolstencroft
Studies: A time course analysis of transcription response in yeast treated with ..., Can yeast glycolysis be understood in terms of in vitro kinetics of the ...
Assays: Changes in flux on the metabolome, Changes in flux on the proteome, Changes in flux on the transcriptome, Glycolysis in Saccharomyces cerevisiae, Time course analysis of transcription
Snapshots: Snapshot 1
Glycolysis in Saccharomyces cerevisiae
Biological problem addressed: Metabolism
Investigation: Growth control of the eukaryote cell: a systems...
Organisms: Saccharomyces cerevisiae (chemostat)
Models: Teusink and 1 hidden item
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
This model is for a paper that examines whether the in vivo behavior of yeast glycolysis can be understood in terms of the in vitro kinetic properties of the constituent enzymes. In non-growing, anaerobic, compressed Saccharomyces cerevisiae the values of the kinetic parameters of most glycolytic enzymes were determined. For the other enzymes appropriate literature values were collected. By inserting these values into a kinetic model for glycolysis, fluxes and metabolites were calculated. Under ...
Creator: Stuart Owen
Submitter: Stuart Owen
Model type: Not specified
Model format: SBML
Environment: Not specified
Organism: Saccharomyces cerevisiae
Investigations: Growth control of the eukaryote cell: a systems...
Studies: Can yeast glycolysis be understood in terms of ...