Modeling the cell division cycle: cdc2 and cyclin interactions

Abstract:

The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.

SEEK DEMO ID: https://demo.sysmo-db.org/publications/24

PubMed ID: 1831270

Projects: FAIRDOM training

Journal: Proc Natl Acad Sci U S A

Citation: Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7328-32.

Date Published: 15th Aug 1991

Author: J. J. Tyson

help Creator
Activity

Views: 513

Created: 5th Dec 2016 at 10:34

help Attributions

None

help Scales
Not Specified

Related items

Powered by
Seek new full
(v.1.4.1)
Copyright © 2008 - 2017 The University of Manchester and HITS gGmbH